Now That's What I Call Music! 78 was released on April 30, 2021. The album is the seventy-eighth edition of the (U.S.) Now series. It peaked at number 1, 3 and 15 on the Billboard 200 and has been certified 2x Platinum by the RIAA. The compilation includes three songs which reached the #1 on the Billboard Hot 100: "drivers license", "willow", & "Heat Waves".
The cover is based off the NOW 106 UK cover, which was released in 2020.