Now That's What I Call Music! 80 was released on October 29, 2021. The album is the eightieth edition of the (U.S.) Now series. It peaked at number 1 and 11 on the Billboard 200 and has been certified 2x Platinum by the RIAA. The compilation includes two songs which reached the #1 on the Billboard Hot 100: "good 4 u" and "RAPSTAR".
The cover is inspired by the NOW 100 UK cover released in 2018.